The Silver Brain is a supervillain, one of the recurring enemies of the First Family. Formerly a regular human scientist named Sergei Vlataroff, he sought a way to transform himself into pure mental energy. Through unknown means, he succeeded, and tried to use his newfound powers to conquer the world, but was opposed by the First Family, kicking off a long enmity with them.

Sometime later, he fought Samaritan and was banished to the Mentoverse. He eventually managed to break out, but was defeated by Astra Furst, who shut down the machine that had enabled him to physically manifest himself.